Nakajima S, Takemura T, Sakata I
Division of Surgical Operation, Asahikawa Medical College, Hokkaido University, Sapporo, Japan.
Cancer Lett. 1995 May 25;92(1):113-8. doi: 10.1016/0304-3835(95)03762-l.
We spectrochemically analyzed 12 Ga-Metal porphyrins (Ga-Cn-P) with different degrees of hydrophobicity, and observed a close association between the in vivo Ga-Cn-P localization in the tumor and its affinity to transferrin and LDL. Image analysis of tumors with 99m-Tc-STA-R12, a porphyrin-scintigraphic agent, revealed STA-R12 localization in the tumor tissue alone about 1 h after intravenous infusion. Our results suggest the importance of endocytosis mediated by transferrin as well as LDL that have been reported as a mechanism of the tumor-localizing activity of porphyrin.
我们对12种具有不同疏水程度的镓金属卟啉（Ga-Cn-P）进行了光谱化学分析，观察到肿瘤内Ga-Cn-P的体内定位与其对转铁蛋白和低密度脂蛋白（LDL）的亲和力之间存在密切关联。用卟啉闪烁显像剂99m-Tc-STA-R12对肿瘤进行图像分析显示，静脉注射后约1小时，STA-R12仅定位于肿瘤组织。我们的结果表明，由转铁蛋白以及低密度脂蛋白介导的内吞作用很重要，而这已被报道为卟啉肿瘤定位活性的一种机制。
