Nakajima S, Hayashi H, Omote Y, Yamazaki Y, Hirata S, Maeda T, Kubo Y, Takemura T, Kakiuchi Y, Shindo Y
Department of Surgery, Asahikawa Medical College, Japan.
J Photochem Photobiol B. 1990 Nov;7(2-4):189-98. doi: 10.1016/1011-1344(90)85156-q.
The tumour-localizing abilities of various kinds of porphyrin derivatives in tumour-bearing hamsters were assessed by nitrogen-pulsed laser spectrofluorometry (N2-PLS). On examination of porphine derivatives (from haemoglobin), it was found that the dimer and acetylated and amidated compounds had a high affinity for tumour tissue; the dimer and hydroxylated compound of phorbine derivatives (from chlorophyll) also showed a high affinity. Furthermore, of the metalloporphines (gallium, zinc and indium complexes), those which contained hydrophilic groups showed a high affinity for tumour tissue; of the metallophorbines (gallium, zinc and indium complexes), those which contained hydrophobic groups showed a high affinity. A correlation was found between the side-chain structure of the porphyrins and metalloporphyrins and their affinity for tumour tissue.
通过氮脉冲激光荧光光谱法（N2-PLS）评估了各种卟啉衍生物在荷瘤仓鼠体内的肿瘤定位能力。在检查来自血红蛋白的卟吩衍生物时，发现二聚体以及乙酰化和酰胺化化合物对肿瘤组织具有高亲和力；来自叶绿素的脱镁叶绿酸衍生物的二聚体和羟基化化合物也表现出高亲和力。此外，在金属卟啉（镓、锌和铟配合物）中，含有亲水基团的那些对肿瘤组织具有高亲和力；在金属脱镁叶绿酸（镓、锌和铟配合物）中，含有疏水基团的那些表现出高亲和力。发现卟啉和金属卟啉的侧链结构与其对肿瘤组织的亲和力之间存在相关性。
