Tatarko S V, Klymenko M O
Fiziol Zh (1994). 1994 Mar-Apr;40(2):100-3.
The model of acute E. coli-induced infectious peritonitis in rats has been used to show that the late reparative stage of acute inflammation is followed by repopulation and regranulation of mast cells. The number of mast cells in the peritoneal fluid and mesrnterium vas resuscitated at the 90th day. At the same time regranulation of peritoneal mast cells was retarded in comparison with that of mast cells of the mesenterium and was not yet over by the 120th day. The increased degranulation of mast cells and free histamine content in the peritoneal fluid and mesenterium and histamine concentration in the blood testified to probable active role of mast cells in lste reparative events on the site of scute inflammation.
大鼠急性大肠杆菌诱导的感染性腹膜炎模型已被用于表明，急性炎症的晚期修复阶段之后是肥大细胞的重新聚集和再颗粒化。在第90天时，腹膜液和肠系膜血管中肥大细胞的数量得以恢复。与此同时，与肠系膜肥大细胞相比，腹膜肥大细胞的再颗粒化受到抑制，到第120天时仍未完成。肥大细胞脱颗粒增加、腹膜液和肠系膜中游离组胺含量增加以及血液中组胺浓度升高，证明肥大细胞在急性炎症部位的晚期修复事件中可能发挥积极作用。
