Klimenko N A, Tatarko S V
Morfologiia. 1996;109(1):51-6.
Regularities of rat mast cells (MC) repopulation and regranulation in late reparative stage of inflammation compared to that in conditions approximating to MC natural renewal (after their osmiophilic elimination) and MC restoration after the inflammation caused during their absence were established on the model of E.coli induced acute infectious peritonitis. MC number in peritoneal fluid and mesenterium restores by 90th day in typical development of the inflammation, with peritoneal MC regranulation yielding to that in mesenterium and remaining unfinished by 120th day. MC repopulation in peritoneal fluid and mesenterium forestalls the one observed after the osmotic MC elimination. Inflammation, induced during MC absence retards peritoneal MC regranulation and promotes that of mesenterial ones. MC repopulation and regranulation on the site of inflammation combines their degranulation and high content of free histamine in peritoneal fluid and mesenterium.
在大肠杆菌诱导的急性感染性腹膜炎模型上，确定了炎症后期修复阶段大鼠肥大细胞（MC）再填充和再颗粒化的规律，并与接近MC自然更新的条件下（嗜锇性消除后）以及在其缺失期间引起炎症后MC的恢复情况进行了比较。在炎症的典型发展过程中，腹膜液和肠系膜中的MC数量在第90天时恢复，腹膜MC的再颗粒化比肠系膜中的再颗粒化慢，到第120天时仍未完成。腹膜液和肠系膜中MC的再填充先于渗透MC消除后观察到的情况。在MC缺失期间诱导的炎症会延迟腹膜MC的再颗粒化，并促进肠系膜MC的再颗粒化。炎症部位的MC再填充和再颗粒化伴随着它们的脱颗粒以及腹膜液和肠系膜中游离组胺的高含量。
