Swierczek J, Kwiecień N, Oleksy J, Konturek S J
Acta Physiol Pol. 1976 Mar-Apr;27(2):131-8.
In 14 healthy male volunteers the effect of 16,16-dimethyl PGE2 methyl ester (PG/D) on gastric secretion have been studied. Gastric secretion was stimulated by an intravenous infusion of pentagastrin (2 mug/kg/h) with gastric juice collected by aspiration or by a pepton meal with acid secretion determined by intragastric titration technique. Intragastrical administration of PG(D) resulted in a strong decrease of gastric acid and pepsin secretion in tests with pentagastrin. PG(D) caused almost complete inhibition of gastric acid response to a pepton meal accompanied by a marked decline of pepsin concentration in the gastric juice as well as significant reduction in the serum level of immunoassayable gastrin. No side effects were noted during or in succeeding 24 hours after administration of PG(D).
在14名健康男性志愿者中，研究了16,16 - 二甲基前列腺素E2甲酯（PG/D）对胃液分泌的影响。通过静脉输注五肽胃泌素（2微克/千克/小时）刺激胃液分泌，采用抽吸法收集胃液，或通过蛋白胨餐，采用胃内滴定技术测定胃酸分泌。在五肽胃泌素试验中，胃内给予PG(D)导致胃酸和胃蛋白酶分泌显著减少。PG(D)几乎完全抑制了对蛋白胨餐的胃酸反应，同时胃液中胃蛋白酶浓度显著下降，血清中可免疫测定的胃泌素水平也显著降低。在给予PG(D)期间及之后的24小时内未观察到副作用。
