Effect of 16, 16-dimethyl prostaglandin E2 methyl ester on gastric secretion induced by pentagastrin and pepton meal in man.

In 14 healthy male volunteers the effect of 16,16-dimethyl PGE2 methyl ester (PG/D) on gastric secretion have been studied. Gastric secretion was stimulated by an intravenous infusion of pentagastrin (2 mug/kg/h) with gastric juice collected by aspiration or by a pepton meal with acid secretion determined by intragastric titration technique. Intragastrical administration of PG(D) resulted in a strong decrease of gastric acid and pepsin secretion in tests with pentagastrin. PG(D) caused almost complete inhibition of gastric acid response to a pepton meal accompanied by a marked decline of pepsin concentration in the gastric juice as well as significant reduction in the serum level of immunoassayable gastrin. No side effects were noted during or in succeeding 24 hours after administration of PG(D).