Anderson D M, Johnson L, Glaccum M B, Copeland N G, Gilbert D J, Jenkins N A, Valentine V, Kirstein M N, Shapiro D N, Morris S W
Immunex Research and Development Corporation, Seattle, Washington 98101, USA.
Genomics. 1995 Feb 10;25(3):701-6. doi: 10.1016/0888-7543(95)80013-c.
Interleukin-15 (IL-15) is a novel cytokine whose effects on T-cell activation and proliferation are similar to those of interleukin-2 (IL-2), presumably because IL-15 utilizes the beta and gamma chains of the IL-2 receptor. Murine IL-15 cDNA and genomic clones were isolated and characterized. The murine Il15 gene was found to consist of eight exons spanning at least 34 kb and was localized to the central region of mouse chromosome 8 by interspecific backcross analysis. Intron positions in a partial human IL15 genomic clone were identical with positions of corresponding introns in the murine gene. The human IL15 gene was mapped to human chromosome 4q31 by fluorescence in situ hybridization.
白细胞介素-15（IL-15）是一种新型细胞因子，其对T细胞激活和增殖的作用与白细胞介素-2（IL-2）相似，这可能是因为IL-15利用了IL-2受体的β链和γ链。分离并鉴定了小鼠IL-15 cDNA和基因组克隆。发现小鼠Il15基因由八个外显子组成，跨越至少34 kb，并通过种间回交分析定位到小鼠染色体8的中央区域。人IL15基因组克隆部分中的内含子位置与小鼠基因中相应内含子的位置相同。通过荧光原位杂交将人IL15基因定位到人类染色体4q31。
