人及小鼠中胆囊收缩素胃和脑受体（CCKAR和CCKBR）的染色体定位
Chromosomal localization of the gastric and brain receptors for cholecystokinin (CCKAR and CCKBR) in human and mouse.
作者信息
Huppi K, Siwarski D, Pisegna J R, Wank S
机构信息
Molecular Genetics Section, Laboratory of Genetics, NCI/NIH, Bethesda, Maryland 20892, USA.
出版信息
Genomics. 1995 Feb 10;25(3):727-9. doi: 10.1016/0888-7543(95)80018-h.
Abstract
Receptors for cholcystokinin (CCK) can be pharmacologically classified into at least two distinct subtypes, CCKAR and CCKBR. In an effort to determine whether the CCKA and CCKB receptors may be associated with certain CNS or gastrointestinal diseases, we have localized and compared the human and mouse chromosomal loci encoded by the CCKAR and CCKBR genes. The gene encoding the CCKA receptor maps to a syntenic region of human chromosome 4 and mouse chromosome 5. The CCKB receptor gene, on the other hand, resides on a syntenic region of human chromosome 11 and distal mouse chromosome 7. Localization of the CCK receptors with two dopamine receptors, DRD5 (4p15.1-p15.3) and DRD4 (11p15), provides the interesting possibility of coinvolvement in neuropsychiatric or CNS illnesses.
摘要
胆囊收缩素（CCK）受体在药理学上可至少分为两种不同的亚型，即CCKAR和CCKBR。为了确定CCKA和CCKB受体是否可能与某些中枢神经系统（CNS）或胃肠道疾病相关，我们对由CCKAR和CCKBR基因编码的人类和小鼠染色体位点进行了定位和比较。编码CCKA受体的基因定位于人类4号染色体和小鼠5号染色体的同线区域。另一方面，CCKB受体基因位于人类11号染色体和小鼠7号染色体远端的同线区域。CCK受体与两种多巴胺受体DRD5（4p15.1 - p15.3）和DRD4（11p15）的定位，为其参与神经精神疾病或中枢神经系统疾病提供了有趣的可能性。
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