Jaggi N, Rajeshwari S, Mittal S K, Mathur M D, Baveja U K
Department of Microbiology and Paediatrics, Maulana Azad Medical College, New Delhi.
J Commun Dis. 1994 Dec;26(4):181-5.
Cryptosporidium oocysts were detected microscopically in the concentrated faecal smears (stained by modified kinyoun's acid fast stain) in 13 out of 100 (13 per cent) cases of acute diarrhoea (AD < 2 weeks duration), 7 out of 50 (14 per cent) cases of chronic diarrhoea (CD > 2 weeks duration) and none in 50 age matched controls. The grades of malnutrition of the cases and controls were calculated by the weight for age criteria and the immune status assessed by the levels of serum immunoglobulins and SIgA in duodenal fluids. Malnutrition was observed in 6 out of 13 cases (46.1 per cent) in acute and 6 out of 7 cases (85.71 per cent) in chronic cryptosporidial diarrhoeas. There was no significant statistical difference (P > 0.05) in serum immunoglobulins and SIgA levels in chronic cryptosporidiosis. SIgA was significantly reduced (P > 0.05) in cases of acute cryptosporidiosis. Cryptosporidium is an important cause of symptomatic infection in apparently immunocompetent children not having been detected in a single non-diarrhoeal control. Further a low SIgA could contribute to acute symptomatic cryptosporidiosis by favouring colonization with the parasite.
在100例急性腹泻（病程<2周）病例中，有13例（13%）通过显微镜检查在浓缩粪便涂片（用改良金胺酚抗酸染色法染色）中检测到隐孢子虫卵囊；50例慢性腹泻（病程>2周）病例中有7例（14%）检测到，而50例年龄匹配的对照中未检测到。根据年龄别体重标准计算病例和对照的营养不良程度，通过血清免疫球蛋白水平和十二指肠液中分泌型免疫球蛋白A（SIgA）评估免疫状态。急性隐孢子虫腹泻的13例病例中有6例（46.1%）观察到营养不良，慢性隐孢子虫腹泻的7例病例中有6例（85.71%）观察到营养不良。慢性隐孢子虫病患者的血清免疫球蛋白和SIgA水平无显著统计学差异（P>0.05）。急性隐孢子虫病患者的SIgA显著降低（P>0.05）。隐孢子虫是明显免疫功能正常儿童有症状感染的重要原因，在非腹泻对照中未检测到。此外，低水平的SIgA可能通过促进寄生虫定植而导致急性症状性隐孢子虫病。
