Castagnola E, Garaventa A, Viscoli C, Carrega G, Nantron M, Molinari C, Moroni C, Giacchino R
Department of Infectious Diseases, G. Gaslini Children's Hospital, Genoa, Italy.
J Hosp Infect. 1995 Feb;29(2):129-33. doi: 10.1016/0195-6701(95)90194-9.
The incidence of pathogens causing catheter-related bacteraemias in children undergoing antineoplastic chemotherapy with or without bone marrow transplantation at G. Gaslini Children's Hospital, Genoa, Italy, was analysed by comparing data from a retrospective study (1985-1988) with that obtained from a prospective one (1989-1992). In both periods catheter-related bacteraemias one (1989-1992). In both periods catheter-related bacteraemias were more frequent in non-neutropenic than in neutropenic patients. Among catheter-unrelated bacteraemias the pattern of infecting pathogens remained unchanged between the study periods, with Gram-positive bacteria remaining the predominant pathogens. Conversely, among catheter-related bacteraemias, the incidence of Gram-negative bacilli increased significantly from 3 to 38%, and that of Gram-positive bacteria fell from 63 to 32% (P = 0.001, chi 2 test for heterogeneity.
通过比较意大利热那亚市G. Gaslini儿童医院接受或未接受骨髓移植的抗肿瘤化疗儿童中与导管相关菌血症的病原体发生率，对一项回顾性研究（1985 - 1988年）的数据与前瞻性研究（1989 - 1992年）的数据进行了分析。在两个时期，与导管相关的菌血症在非中性粒细胞减少患者中比在中性粒细胞减少患者中更常见。在与导管无关的菌血症中，研究期间感染病原体的模式保持不变，革兰氏阳性菌仍然是主要病原体。相反，在与导管相关的菌血症中，革兰氏阴性杆菌的发生率从3%显著增加到38%，革兰氏阳性菌的发生率从63%降至32%（P = 0.001，异质性卡方检验）。
