Crompton N E, Saydan N
Institute for Medical Radiobiology, Paul Scherrer Institute, Villigen, Switzerland.
J Neurooncol. 1994;22(3):255-9. doi: 10.1007/BF01052930.
Cell biology has made major progress in identifying the molecules that drive the cell cycle. The evidence accumulating from these studies indicates that derangements in the cell cycle machinery contribute to the uncontrolled cell growth of tumours. The cell cycle machinery has been found to be substantially altered in tumour cells and also may be crucial for carcinogenesis. In this context, various aspects of tumour cell growth have been studied in an effort to understand 1) why tumour cells display uncontrolled growth, 2) why radiation selectively affects growing cells, and 3) whether aspects of the cell cycle and tumour cell growth may be used in tumour diagnosis and prognosis.
细胞生物学在识别驱动细胞周期的分子方面取得了重大进展。这些研究积累的证据表明，细胞周期机制的紊乱会导致肿瘤细胞的失控生长。人们发现肿瘤细胞中的细胞周期机制发生了显著改变，并且可能对肿瘤发生至关重要。在这种背景下，人们对肿瘤细胞生长的各个方面进行了研究，以试图理解：1）肿瘤细胞为何表现出失控生长；2）为什么辐射会选择性地影响正在生长的细胞；3）细胞周期和肿瘤细胞生长的各个方面是否可用于肿瘤的诊断和预后判断。
