Moe L, Heiene R
Department of Small Animal Clinical Sciences, Norwegian College of Veterinary Medicine, Oslo.
Res Vet Sci. 1995 Mar;58(2):138-43. doi: 10.1016/0034-5288(95)90067-5.
The glomerular filtration rates (GFR) of 18 dogs of different breeds were estimated by simultaneously comparing the plasma decay curves of 99M-Tc-diethylenetriaminepentaacetic acid (Tc-DTPA) and the contrast medium iohexol. Nine of the dogs were clinically healthy, and nine had renal disease. After the intravenous injection of the two substances, nine to 12 blood samples were taken during the first six hours and in some cases up to 24 hours. The total clearance of the substances was determined by one- and two-compartment models. Individual GFRiohexol values, estimated by using a two-compartment model in 16 of the dogs, ranged from 39.0 ml min-1 m-2 to 84.3 ml min-1 m-2 and for GFRTc-DTPA from 41.1 ml min-1 m-2 to 106.6 ml min-1 m-2. The GFRiohexol values estimated by using a one-compartment model in the 18 dogs ranged from 4.52 ml min-1 m-2 to 105 ml min-1 m-2 and for GFRTc-DTPA from 5.4 ml min-1 m-2 to 118.9 ml min-1 m-2. The agreement between the two methods was good, as shown by a limits of agreement plot. The ratio of GFRTc-DTPA/GFRiohexol was 1.15 throughout the range of measurement (SD = 0.085). The study indicates that the iohexol method is a valid measure of GFR in the dog. The practical aspects make it a useful tool in small animal practice.
通过同时比较99M-锝-二乙三胺五乙酸（Tc-DTPA）和造影剂碘海醇的血浆衰变曲线，估算了18只不同品种犬的肾小球滤过率（GFR）。其中9只犬临床健康，9只患有肾脏疾病。静脉注射这两种物质后，在前6小时内采集了9至12份血样，在某些情况下直至24小时。通过一室和二室模型确定物质的总清除率。在16只犬中使用二室模型估算的个体碘海醇GFR值范围为39.0毫升·分钟⁻¹·米⁻²至84.3毫升·分钟⁻¹·米⁻²，Tc-DTPA的GFR值范围为41.1毫升·分钟⁻¹·米⁻²至106.6毫升·分钟⁻¹·米⁻²。在18只犬中使用一室模型估算的碘海醇GFR值范围为4.52毫升·分钟⁻¹·米⁻²至105毫升·分钟⁻¹·米⁻²，Tc-DTPA的GFR值范围为5.4毫升·分钟⁻¹·米⁻²至118.9毫升·分钟⁻¹·米⁻²。一致性界限图显示两种方法之间的一致性良好。在整个测量范围内，Tc-DTPA/GFR碘海醇的比值为1.15（标准差=0.085）。该研究表明，碘海醇法是犬GFR的有效测量方法。其实际应用方面使其成为小动物临床实践中的有用工具。
