[天然免疫刺激剂“Vegetan”对小鼠疱疹性脑膜脑炎、豚鼠生殖器疱疹和犬细小病毒肠炎的抗病毒活性]

[Antiviral activity of the natural immunostimulant "Vegetan" in murine herpetic meningoencephalitis, guinea pig genital herpes, and canine parvoviral enteritis].

作者信息

L'vov N D, Chekanovskaia L A, Alimbarova L M, Mel'nikov V R, Zontov S V, Slepushkin V A, Barinskiĭ I F

出版信息

Vopr Virusol. 1995 Mar-Apr;40(2):85-9.

Abstract

Antiviral activity of vegetan, a new natural immunostimulator, in herpetic meningoencephalitis of mice, genital herpes of guinea pigs, and parvoviral enteritis of dogs was compared to that of acylguanosine and phosphonoformic acid (PFA). Vegetan incorporated in liposomes or pure was the most active if used for prevention 5 days before intracerebral infection of mice with herpes simplex type 1 virus, whatever the dose of infective agent (10 to 100 LD50). Protective efficacy of vegetan was 57-63%, whereas for ara-A, acylguanosine, and PFA these values were, respectively, 20, 25, and 33%. Use of liposomal vegetan preparation ensured a 80% protective effect. Vegetan had a manifest antiviral effect in guinea pigs with genital herpes and in dogs with parvoviral enteritis.

摘要

将一种新型天然免疫刺激剂Vegetan在小鼠疱疹性脑膜脑炎、豚鼠生殖器疱疹和犬细小病毒性肠炎中的抗病毒活性与阿糖腺苷和膦甲酸（PFA）进行了比较。如果在小鼠脑内感染1型单纯疱疹病毒前5天用于预防，无论感染剂剂量如何（10至100 LD50），包裹在脂质体中的Vegetan或纯品Vegetan活性最高。Vegetan的保护效果为57-63%，而阿糖腺苷、酰基鸟苷和PFA的相应值分别为20%、25%和33%。使用脂质体Vegetan制剂可确保80%的保护效果。Vegetan在患有生殖器疱疹的豚鼠和患有细小病毒性肠炎的犬中具有明显的抗病毒作用。