Dahllund L, Nissinen L, Pulli T, Hyttinen V P, Stanway G, Hyypiä T
Department of Virology and MediCity Research Laboratory, University of Turku, Finland.
Virus Res. 1995 Feb;35(2):215-22. doi: 10.1016/0168-1702(94)00104-k.
Echoviruses are the largest enterovirus subgroup consisting of 32 serotypes. They are common human pathogens causing, for example, meningitis, encephalitis and exanthema, but in spite of their clinical importance, relatively little is known about their biology. To illuminate the molecular characteristics of echoviruses, we have completed the genomic sequence of serotype 11. The RNA genome is 7438 nucleotides in length and it codes for a 2195 amino acid long polyprotein. When compared to other sequenced enteroviruses, echovirus 11 (EV11) shows remarkable similarity with coxsackie B viruses (CBVs) and coxsackievirus A9 (CAV9). On the basis of amino acid sequence homology in the capsid region, CAV9 is the virus most closely related to EV11. These two viruses have an apparent insertion sequence located at the C-terminus of the VP1 polypeptide. EV11, however, lacks the RGD motif found in the corresponding region of CAV9. The organization of the 5' end noncoding region resembles that of other enteroviruses, but contains a 12 nucleotides long poly-U stretch not seen in any other enterovirus sequenced to date.
埃可病毒是肠道病毒中最大的一个亚群，由32个血清型组成。它们是常见的人类病原体，可引起例如脑膜炎、脑炎和皮疹等疾病，但尽管它们具有临床重要性，人们对其生物学特性的了解相对较少。为了阐明埃可病毒的分子特征，我们完成了11型血清型的基因组序列测定。RNA基因组长度为7438个核苷酸，编码一个长度为2195个氨基酸的多聚蛋白。与其他已测序的肠道病毒相比，埃可病毒11型（EV11）与柯萨奇B组病毒（CBVs）和柯萨奇A9病毒（CAV9）表现出显著的相似性。基于衣壳区域的氨基酸序列同源性，CAV9是与EV11关系最密切的病毒。这两种病毒在VP1多肽的C末端有一个明显的插入序列。然而，EV11在CAV9相应区域中发现的RGD基序缺失。5'端非编码区的结构与其他肠道病毒相似，但包含一个12个核苷酸长的多聚U序列，这在迄今为止测序的任何其他肠道病毒中都未见过。
