Zhang G, Wilsden G, Knowles N J, McCauley J W
AFRC Institute for Animal Health, Pirbright Laboratory, Woking, U.K.
J Gen Virol. 1993 May;74 ( Pt 5):845-53. doi: 10.1099/0022-1317-74-5-845.
We report the first complete nucleotide sequence of the picornavirus coxsackievirus B5 (CB5), strain 1954/UK/85, an isolate from a case of hand-foot-and-mouth disease. We have compared the sequence with those of other coxsackie B viruses, coxsackievirus A9, poliovirus and swine vesicular disease virus (SVDV). The genes encoding the three major capsid proteins are most closely related to those of SVDV but the 5' and 3' noncoding regions and the P3 gene are more similar to the corresponding regions in the other coxsackie B viruses than to those of SVDV. These observations are considered in the light of the antigenic and biochemical relationships between SVDV and CB5.
我们报道了肠道病毒柯萨奇病毒B5（CB5）1954/UK/85株的首个完整核苷酸序列，该毒株分离自一例手足口病病例。我们已将该序列与其他柯萨奇B组病毒、柯萨奇病毒A9、脊髓灰质炎病毒和猪水疱病病毒（SVDV）的序列进行了比较。编码三种主要衣壳蛋白的基因与SVDV的最为密切相关，但5'和3'非编码区以及P3基因与其他柯萨奇B组病毒的相应区域比与SVDV的更为相似。根据SVDV和CB5之间的抗原及生化关系对这些观察结果进行了考量。
