Kuralesova A I
Biull Eksp Biol Med. 1975 May;79(5):111-4.
It was found that bone marrow obtained from the tibium or the femur (locally irradiated with 2000 R) and transplanted subcapsularly into the kidney of mice of the same strain 0-4 months after the irradiation was always resorpted. As to the bone marrow from the nonirradiated bones of the same donors--it always possessed osteogenic potencies. Stroma of the irradiated limb was defective ang failed to regenerate at the expense of repopulation of the stroma elements from the nonirradiated sections. Analogous conclusions were drawn on the basis of the experimental results with repeated irradiation of mice with the shielded extremity. In difference to the hemopoietic, stromal elements were incapable of repopulation (according to the data of heterotopic transplantation).
研究发现,从胫骨或股骨获取的骨髓(局部照射2000伦琴),在照射后0至4个月,经包膜下移植到同品系小鼠的肾脏中,总会被吸收。至于来自相同供体未照射骨骼的骨髓——它始终具有成骨能力。照射肢体的基质存在缺陷,无法通过未照射部位的基质成分重新填充来实现再生。基于对小鼠屏蔽肢体进行重复照射的实验结果,得出了类似结论。与造血细胞不同,基质成分无法实现重新填充(根据异位移植的数据)。