Kida Y, Maeda M, Iwata S, Iwashita Y, Goto K, Nishi K
Life Science Laboratories, Central Research Laboratories Ajinomoto, Co., Inc., Yokohama, Japan.
Artif Organs. 1995 Feb;19(2):117-28. doi: 10.1111/j.1525-1594.1995.tb02300.x.
The effects of pyridoxalated hemoglobin polyoxyethylene conjugate (PHP) and other hemoglobin-related substances on arterial blood pressure (ABP) and heart rate (HR) were examined. Infusion of PHP and other hemoglobin-related substances elevated ABP and increased HR. The degree of the increase in ABP and HR did not differ among the groups. There were species' differences in responses to PHP. Pretreatment with various blockers did not abolish the elevation of ABP. The pretreatment of NG-monomethyl-L-arginine dose-dependently reduced the elevation of ABP but did not completely abolish it. PHP also elevated ABP in conscious rats. The magnitude of the ABP elevation was significantly smaller than in the anesthetized rats. Results indicate that inhibition of nitric oxide (NO) might be responsible in part for the elevation of ABP, and the degree of the elevation would be dependent on the degree of contribution of NO to the regulation of ABP.
研究了吡哆醛化血红蛋白聚氧乙烯共轭物（PHP）及其他与血红蛋白相关的物质对动脉血压（ABP）和心率（HR）的影响。输注PHP及其他与血红蛋白相关的物质可使ABP升高并使HR增加。各实验组中ABP和HR升高的程度并无差异。对PHP的反应存在物种差异。用各种阻滞剂进行预处理并不能消除ABP的升高。用NG-单甲基-L-精氨酸进行预处理可剂量依赖性地降低ABP的升高，但不能完全消除。PHP也可使清醒大鼠的ABP升高。ABP升高的幅度显著小于麻醉大鼠。结果表明，一氧化氮（NO）的抑制可能部分导致了ABP的升高，且升高的程度取决于NO对ABP调节的贡献程度。
