1型糖尿病和甲状腺胃自身免疫具有不同遗传决定因素的证据。
Evidence that type I diabetes and thyrogastric autoimmunity have different genetic determinants.
作者信息
Gorsuch A N, Dean B M, Bottazzo G F, Lister J, Cudworth A G
出版信息
Br Med J. 1980 Jan 19;280(6208):145-7. doi: 10.1136/bmj.280.6208.145.
Abstract
The prevalences of autoimmune endocrine disease and relevant organ-specific autoantibodies were determined in 141 patients with type I (insulin-dependent) diabetes and their families. All available members of the families were genotyped for HLA. Islet-cell antibody was found in 10 (4%) out of 248 unaffected siblings, all of whom were genetically potential cases of diabetes. One developed classical symptoms six months later. In contrast, thyroid and gastric parietal-cell antibodies occurred independent of the HLA-linked susceptibility to diabetes. These results suggest that different genes control the production of these autoantibodies and the susceptibility to type I diabetes.
摘要
对141例I型（胰岛素依赖型）糖尿病患者及其家族成员进行了自身免疫性内分泌疾病及相关器官特异性自身抗体的患病率测定。对家族中所有可获得的成员进行了HLA基因分型。在248名未患病的兄弟姐妹中，有10名（4%）检测到胰岛细胞抗体，他们均为糖尿病的潜在遗传病例。其中1人在6个月后出现了典型症状。相比之下，甲状腺和胃壁细胞抗体的出现与HLA相关的糖尿病易感性无关。这些结果表明，不同的基因控制着这些自身抗体的产生以及I型糖尿病的易感性。
相似文献
1
Evidence that type I diabetes and thyrogastric autoimmunity have different genetic determinants.1型糖尿病和甲状腺胃自身免疫具有不同遗传决定因素的证据。
Br Med J. 1980 Jan 19;280(6208):145-7. doi: 10.1136/bmj.280.6208.145.
2
Islet-cell, thyroid, and gastric autoantibodies in diabetic identical twins.糖尿病同卵双胞胎中的胰岛细胞、甲状腺及胃自身抗体。
Br Med J. 1976 Mar 6;1(6009):553-5. doi: 10.1136/bmj.1.6009.553.
3
A search for heterogeneity in insulin dependent diabetes mellitus (IDDM): HLA and autoimmune studies in simplex, multiplex and multigenerational families.
Metabolism. 1983 May;32(5):471-7. doi: 10.1016/0026-0495(83)90009-4.
4
Autoimmunity in juvenile diabetics and their families.青少年糖尿病患者及其家族中的自身免疫
Br Med J. 1978 Jul 15;2(6131):165-8. doi: 10.1136/bmj.2.6131.165.
5
HLA-linked genes and islet-cell antibodies in diabetes mellitus.糖尿病中的HLA连锁基因与胰岛细胞抗体
Br Med J. 1976 Jun 26;1(6025):1565-7. doi: 10.1136/bmj.1.6025.1565.
6
[Autoimmunological phenomena in diabetes, particularly of the juvenile type].[糖尿病中的自身免疫现象，尤其是青少年型糖尿病]
Pol Tyg Lek. 1977 Sep 26;32(39):1525-7.
7
Organ-specific autoimmunity and genetic predisposition in interferon-treated HCV-related chronic hepatitis patients.干扰素治疗的丙型肝炎病毒相关慢性肝炎患者的器官特异性自身免疫和遗传易感性
Ital J Gastroenterol Hepatol. 1998 Feb;30(1):71-6.
8
Autoimmunity in type I (insulin-dependent) diabetes mellitus in North India.印度北部I型（胰岛素依赖型）糖尿病中的自身免疫
J Clin Immunol. 1981 Jul;1(3):169-73. doi: 10.1007/BF00922759.
9
Organ specificity in autoimmune diseases: thyroid and islet autoimmunity in alopecia areata.自身免疫性疾病中的器官特异性：斑秃中的甲状腺和胰岛自身免疫
J Clin Endocrinol Metab. 2015 May;100(5):1976-83. doi: 10.1210/jc.2014-3985. Epub 2015 Mar 3.
10
[Role of autoimmune processes in the pathogenesis of diabetes mellitus].[自身免疫过程在糖尿病发病机制中的作用]
Klin Med (Mosk). 1980 Oct;58(10):22-6.
引用本文的文献
1
Presence of the autoantibody in healthy relatives of Italian patients with pemphigus vulgaris.寻常型天疱疮意大利患者健康亲属中自身抗体的存在情况。
Arch Dermatol Res. 1993;285(3):176-7. doi: 10.1007/BF01112924.
2
Coincident presence of thyro-gastric autoimmunity at onset of type 1 (insulin-dependent) diabetes.1型（胰岛素依赖型）糖尿病发病时甲状腺与胃自身免疫同时存在。
Diabetologia. 1983 Jun;24(6):418-21. doi: 10.1007/BF00257339.
3
Evidence for an association between rheumatoid arthritis and autoimmune endocrine disease.类风湿性关节炎与自身免疫性内分泌疾病之间关联的证据。
Ann Rheum Dis. 1983 Jun;42(3):297-300. doi: 10.1136/ard.42.3.297.
4
Analysis of islet cell antibodies on frozen sections of human pancreas.
Diabetologia. 1983 Aug;25(2):93-6. doi: 10.1007/BF00250895.
5
Clinical characteristics and etiological markers in insulin-dependent diabetes associated with an organ-specific autoimmune disease.与器官特异性自身免疫性疾病相关的胰岛素依赖型糖尿病的临床特征及病因学标志物
Acta Diabetol Lat. 1983 Jul-Sep;20(3):221-9. doi: 10.1007/BF02581266.
6
7
Autoantibodies in Indian-Asians with insulin-dependent diabetes in the UK.英国印度裔亚洲胰岛素依赖型糖尿病患者的自身抗体。
Postgrad Med J. 1988 May;64(751):357-60. doi: 10.1136/pgmj.64.751.357.
8
Risk for developing type 1 (insulin-dependent) diabetes mellitus and the presence of islet 64K antibodies.患1型（胰岛素依赖型）糖尿病的风险及胰岛64K抗体的存在情况。
Diabetologia. 1991 Oct;34(10):727-33. doi: 10.1007/BF00401518.
9
Islet cell antibodies in normal French schoolchildren.
Diabetologia. 1992 Jun;35(6):577-82. doi: 10.1007/BF00400487.
本文引用的文献
1
Thyroid and gastric autoimmunity in patients with diabetes mellitus.糖尿病患者的甲状腺和胃部自身免疫
Lancet. 1970 Jul 25;2(7665):163-8. doi: 10.1016/s0140-6736(70)92531-6.
2
Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies.伴有自身免疫性多内分泌腺缺陷的糖尿病中的胰岛细胞抗体。
Lancet. 1974 Nov 30;2(7892):1279-83. doi: 10.1016/s0140-6736(74)90140-8.
3
Evidence for HL-A-linked genes in "juvenile" diabetes mellitus.“青少年”糖尿病中与HL-A相关基因的证据。
Br Med J. 1975 Jul 19;3(5976):133-5. doi: 10.1136/bmj.3.5976.133.
4
Genetic basis of rheumatoid disease: HLA antigens, disease manifestations, and toxic reactions to drugs.类风湿病的遗传基础：HLA抗原、疾病表现及对药物的毒性反应。
Br Med J. 1978 Nov 11;2(6148):1326-8. doi: 10.1136/bmj.2.6148.1326.
5
HLA-A, -B and -C antigens, their serology and cross-reaction.人类白细胞抗原A、B和C抗原、它们的血清学及交叉反应。
Br Med Bull. 1978 Sep;34(3):217-22. doi: 10.1093/oxfordjournals.bmb.a071501.
6
Evidence for a primary autoimmune type of diabetes mellitus.原发性自身免疫性糖尿病的证据。
Br Med J. 1978 Nov 4;2(6147):1253-5. doi: 10.1136/bmj.2.6147.1253.
7
Autoimmunity in juvenile diabetics and their families.青少年糖尿病患者及其家族中的自身免疫
Br Med J. 1978 Jul 15;2(6131):165-8. doi: 10.1136/bmj.2.6131.165.
8
The HLA system, autoimmune endocrinopathy and diabetes mellitus.人类白细胞抗原系统、自身免疫性内分泌病与糖尿病
Eur J Clin Invest. 1978 Dec;8(6):355-7. doi: 10.1111/j.1365-2362.1978.tb00864.x.
9
HLA genetic heterogeneity in diabetes mellitus.糖尿病中的HLA基因异质性。
Br Med Bull. 1978 Sep;34(3):285-9. doi: 10.1093/oxfordjournals.bmb.a071513.
10
Type I diabetes mellitus.1型糖尿病
Diabetologia. 1978 May;14(5):281-91. doi: 10.1007/BF01223018.
Zotero 插件