聚合草苷A，一种从聚合草根部提取的三萜皂苷。

Symphytoxide A, a triterpenoid saponin from the roots of Symphytum officinale.

作者信息

Ahmad V U, Noorwala M, Mohammad F V, Sener B, Gilani A H, Aftab K

机构信息

H.E.J. Research Institute of Chemistry, University of Karachi, Pakistan.

出版信息

Phytochemistry. 1993 Mar;32(4):1003-6. doi: 10.1016/0031-9422(93)85244-l.

DOI:10.1016/0031-9422(93)85244-l

PMID:7763474

Abstract

A new triterpenoidal saponin of hederagenin named symphytoxide A has been isolated from the ethanolic extract of the roots of Symphytum officinale and characterized on the basis of chemical investigations and spectroscopic studies as 3-O-[beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranosyl-(1-->4)- alpha-L-arabinopyranosyl] hederagenin. The structure of this new saponin was established on the basis of 1D and 2D NMR experiments including heteroCOSY, COSY-45 degrees as well as HMBC measurements and other spectroscopic techniques. The saponin exhibited hypotensive activity in anesthetized rats.

摘要

从药用琉璃苣（Symphytum officinale）根的乙醇提取物中分离出一种新的常春藤皂苷元三萜皂苷，命名为聚合草皂苷A，并通过化学研究和光谱学研究鉴定其结构为3-O-[β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃葡萄糖基-(1→4)-α-L-阿拉伯吡喃糖基]常春藤皂苷元。该新皂苷的结构是基于一维和二维核磁共振实验确定的，包括异核相关谱、45° 相关谱以及异核多键相关测量和其他光谱技术。该皂苷在麻醉大鼠中表现出降压活性。