合成甲基甘草次酸糖苷的构效关系

Structure-activity relationships of synthetic methyl glycyrrhetate glycosides.

作者信息

Takechi M, Tanaka Y

机构信息

Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Japan.

出版信息

Phytochemistry. 1993 Mar;32(5):1173-5. doi: 10.1016/s0031-9422(00)95086-6.

DOI:10.1016/s0031-9422(00)95086-6

Abstract

Of 15 synthetic methyl glycyrrhetate glycosides, the monoglycosides having CH2OH-6 or Me-6 in their sugar moieties and the diglycosides having a (1-->4) linkage between the sugar residues showed higher haemolytic activities than the others. The beta-maltoside and beta-lactoside exhibited much stronger antifungal activities against Trichophyton mentagrophytes than the others. However, none of them exhibited antibacterial activity against Staphylococcus aureus or Bacillus subtilis.

摘要

在15种合成甲基甘草次酸糖苷中，糖部分含有CH2OH-6或Me-6的单糖苷以及糖残基之间具有(1→4)连接的二糖苷比其他糖苷表现出更高的溶血活性。β-麦芽糖苷和β-乳糖苷对须癣毛癣菌的抗真菌活性比其他糖苷强得多。然而，它们均未表现出对金黄色葡萄球菌或枯草芽孢杆菌的抗菌活性。

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