合成乌索酸甲酯糖苷的构效关系。

Structure-activity relationships of synthetic methyl ursolate glycosides.

作者信息

Takechi M, Tanaka Y

机构信息

Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Japan.

出版信息

Phytochemistry. 1993 Oct;34(3):675-7. doi: 10.1016/0031-9422(93)85338-r.

DOI:10.1016/0031-9422(93)85338-r

PMID:7764145

Abstract

From 15 synthetic methyl ursolate glycosides, the di- and tri-glycosides showed much higher haemolytic activity than the monoglycosides. The beta-gentiobioside and the beta-maltotrioside exhibited much stronger antibacterial (Staphylococcus aureus) or antifungal (Trichophyton mentagrophytes) activity than the other glycosides. However, none of them exhibited antibacterial activity against Bacillus subtilis.

摘要

在15种合成甲基乌苏酸糖苷中，二糖苷和三糖苷的溶血活性比单糖苷高得多。β-龙胆二糖苷和β-麦芽三糖苷对金黄色葡萄球菌的抗菌活性或对须癣毛癣菌的抗真菌活性比其他糖苷强得多。然而，它们对枯草芽孢杆菌均无抗菌活性。