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合成三萜类和甾体β-D-吡喃葡萄糖基-(1→2)-α-D-吡喃葡萄糖苷的生物活性

Biological activities of synthetic triterpenoid and steroid beta-D-glucopyranosyl-(1-->2)-alpha-D-glucopyranosides.

作者信息

Takechi M, Kousaka Y, Uno C, Tanaka Y

出版信息

Planta Med. 1998 Mar;64(2):179-80. doi: 10.1055/s-2006-957400.

DOI:10.1055/s-2006-957400
PMID:9525112
Abstract

Comparisons of the biological activities of diosgenyl, methyl glycyrrhetinate, or digitoxigenyl 3-O-beta-D-glucopyranosyl-(1-->2)-alpha-D-glucopyranoside with those of other previously tested glycosides confirmed our assumption that both haemolytic and antifungal activities of steroid saponins are generally parallel to each other, while almost all haemolytic triterpenoid saponins have no antifungal activity. The earlier supposition that cardiac diglycosides having a (1-->4) sugar linkage have stronger activities than those with a (1-->6) linkage has been extended by the demonstration of reduced activity also in those with a (1-->2) linkage.

摘要

将薯蓣皂苷元基、甲基甘草次酸基或洋地黄毒苷元基3 - O - β - D - 吡喃葡萄糖基 - (1→2) - α - D - 吡喃葡萄糖苷的生物活性与其他先前测试过的糖苷的生物活性进行比较,证实了我们的假设,即甾体皂苷的溶血活性和抗真菌活性通常彼此平行,而几乎所有溶血三萜皂苷都没有抗真菌活性。早期的推测认为,具有(1→4)糖键的强心二糖苷比具有(1→6)糖键的强心二糖苷活性更强,而现在通过证明具有(1→2)糖键的强心二糖苷活性也降低,这一推测得到了扩展。

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