合成替高皂甙元糖苷的构效关系。

Structure-activity relationships of synthetic tigogenyl glycosides.

作者信息

Takechi M, Tanaka Y

机构信息

Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Japan.

出版信息

Phytochemistry. 1993 Nov;34(5):1241-3. doi: 10.1016/0031-9422(91)80008-o.

DOI:10.1016/0031-9422(91)80008-o

PMID:7764282

Abstract

Haemolytic activities of the five tigogenyl diglycosides and a maltotrioside were much stronger than those of nine monoglycosides. Among these glycosides, the glucoside, galactoside, maltoside, lactoside, gentiobioside, melibioside and maltotrioside had strong antifungal activity. By contrast, none of these glycosides showed any antibacterial activity.

摘要

五种薯蓣皂苷元二糖苷和一种麦芽三糖苷的溶血活性比九种单糖苷的溶血活性强得多。在这些糖苷中，葡萄糖苷、半乳糖苷、麦芽糖苷、乳糖苷、龙胆二糖苷、蜜二糖苷和麦芽三糖苷具有较强的抗真菌活性。相比之下，这些糖苷均未显示出任何抗菌活性。