刺叶棘豆中的生物活性三萜皂苷——刺叶棘豆苷A。

Squarroside A, a biologically active triterpene saponin from Acanthophyllum squarrosum.

作者信息

Lacaille-Dubois M A, Hanquet B, Rustaiyan A, Wagner H

机构信息

Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université de Bourgogne, Dijon, France.

出版信息

Phytochemistry. 1993 Sep;34(2):489-95. doi: 10.1016/0031-9422(93)80036-r.

DOI:10.1016/0031-9422(93)80036-r

PMID:7764142

Abstract

A new bioactive saponin has been isolated from the roots of Acanthophyllum squarrosum. Based on spectroscopic data, especially direct and long-range heteronuclear 2D NMR analysis, and on chemical transformations, the structure of this new compound was elucidated as 3-O-beta-D-galactopyranosyl-(1-->2)-[beta-D-xylopyranosyl-(1-->3)]-beta- D-glucuronopyranosyl gypsogenin 28-O-beta-D-xylopyranosyl-(1-->4)-alpha-L- rhamnopyranosyl-(1-->2)-[alpha-L-arabinofuranosyl-(1-->3)]-beta-D-4-O- acetylfucopyranoside for which we proposed the name squarroside A. This molecule showed a concentration dependent immunomodulatory effect in the in vitro lymphocyte transformation test.

摘要

从刺叶棘豆根部分离出一种新的生物活性皂苷。基于光谱数据，尤其是直接和远程异核二维核磁共振分析，以及化学转化，确定该新化合物的结构为3-O-β-D-吡喃半乳糖基-(1→2)-[β-D-吡喃木糖基-(1→3)]-β-D-吡喃葡糖醛酸基绞股蓝皂苷元28-O-β-D-吡喃木糖基-(1→4)-α-L-吡喃鼠李糖基-(1→2)-[α-L-阿拉伯呋喃糖基-(1→3)]-β-D-4-O-乙酰基吡喃岩藻糖苷，我们将其命名为刺叶棘豆皂苷A。该分子在体外淋巴细胞转化试验中显示出浓度依赖性免疫调节作用。