叉枝蝇子草中的酰化三萜皂苷。

Acylated triterpene saponins from Silene jenisseensis.

作者信息

Lacaille-Dubois M A, Hanquet B, Cui Z H, Lou Z C, Wagner H

机构信息

Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université de Bourgogne, Dijon, France.

出版信息

Phytochemistry. 1995 Sep;40(2):509-14. doi: 10.1016/0031-9422(95)00222-s.

DOI:10.1016/0031-9422(95)00222-s

PMID:7546560

Abstract

From the roots of Silene jenisseensis a new trans-p-methoxycinnamoyl triterpene saponin has been isolated along with its cis-p-methoxycinnamoyl isomer as an inseparable mixture. Their structures were established by chemical means and spectroscopic methods including 1D- and 2D-homonuclear and heteronuclear correlation NMR spectroscopy as 3-O-[beta-D-galactopyranosyl-(1 --> 2)-beta-D-glucuronopyranosyl]-28-O-[beta-D-glucopyranosyl-(1 --> 2)-alpha-L-rhamnopyranosyl- (1 --> 2)-beta-D-4-O-trans-p-methoxycinnamoyl-fucopyranosyl] quillaic acid and its cis-isomer, respectively. They did not show any activity in the in vitro chemoluminescence granulocytes assay, but exhibited only a weak inhibitory effect in the cyclooxygenase inhibition assay.

摘要

从叉歧繁缕的根部分离出一种新的反式对甲氧基肉桂酰三萜皂苷及其顺式对甲氧基肉桂酰异构体，二者为不可分离的混合物。通过化学方法和光谱法，包括一维和二维同核及异核相关核磁共振光谱法确定了它们的结构，分别为3 - O - [β - D - 吡喃半乳糖基 - (1→2) - β - D - 吡喃葡萄糖醛酸基] - 28 - O - [β - D - 吡喃葡萄糖基 - (1→2) - α - L - 鼠李吡喃糖基 - (1→2) - β - D - 4 - O - 反式对甲氧基肉桂酰 - 岩藻吡喃糖基] 齐墩果酸及其顺式异构体。它们在体外化学发光粒细胞试验中未显示任何活性，但在环氧合酶抑制试验中仅表现出微弱的抑制作用。