Faber K, Franssen M C
Institute of Organic Chemistry, Graz University of Technology, Austria.
Trends Biotechnol. 1993 Nov;11(11):461-70. doi: 10.1016/0167-7799(93)90079-O.
Predicting the future use of biocatalysts for the transformation of organic compounds--both natural substrates and other compounds--needs to take many factors into account. To date, relatively few biotransformations have been developed to the industrial scale, primarily because there has been little economic incentive to replace existing successful processes with biocatalysts, with their inherent problems of instability, lack of selectivity and narrow operational range. However, advances that improve biocatalyst performance, coupled with the increasing emphasis on 'chirotechnology', are driving the development of biocatalysis as a complementary, if not a rival technology to existing chemical approaches.
预测生物催化剂未来用于有机化合物（包括天然底物和其他化合物）转化的情况需要考虑诸多因素。迄今为止，相对较少的生物转化过程已发展到工业规模，主要原因是用生物催化剂取代现有的成功工艺几乎没有经济激励，因为生物催化剂存在固有的稳定性问题、缺乏选择性和操作范围狭窄等问题。然而，提高生物催化剂性能的进展，再加上对“手性技术”日益增加的重视，正在推动生物催化作为一种补充技术（即便不是现有化学方法的竞争技术）的发展。
