Saito Y, Wanezaki K, Kawato A, Imayasu S
Research Institute, Gekkeikan Sake Co., Ltd., Kyoto, Japan.
Biosci Biotechnol Biochem. 1994 May;58(5):812-6. doi: 10.1271/bbb.58.812.
Systolic blood pressure (SBP) decreased significantly when the hydrolysate of sake lee (HSL) and peptide fraction of sake (PFS) were orally administrated to spontaneously hypertensive rats (SHR). SBP of "young" SHR decreased significantly after orally administering Val-Tyr, His-Tyr, Arg-Phe, Val-Trp, and Tyr-Trp that were isolated from PFS and HSL. The hypotensive effect of Val-Tyr and His-Tyr that was observed in "young" SHR disappeared as they got older, but PFS and HSL maintained their antihypertensive effect on "aged" SHR. SHR fed on a diet with HSL replacing half of the protein source for 3 weeks showed a significant decrease in SBP after 10 days of feeding.
给自发性高血压大鼠（SHR）口服清酒粕水解物（HSL）和清酒肽组分（PFS）后，收缩压（SBP）显著降低。从PFS和HSL中分离出的Val-Tyr、His-Tyr、Arg-Phe、Val-Trp和Tyr-Trp口服给药后，“年轻”SHR的SBP显著降低。在“年轻”SHR中观察到的Val-Tyr和His-Tyr的降压作用随着年龄增长而消失，但PFS和HSL对“老年”SHR仍保持其降压作用。用HSL替代一半蛋白质来源的饲料喂养SHR 3周，喂养10天后SBP显著降低。
