Kolodner R D, Alani E
Dana Farber Cancer Institute, Boston.
Curr Opin Biotechnol. 1994 Dec;5(6):585-94. doi: 10.1016/0958-1669(94)90079-5.
Mismatch-repair systems have been identified in organisms ranging from Escherichia coli to humans. They can repair almost all DNA base pair mismatches as well as small insertion/deletion mismatches. Molecular and biochemical analyses have shown that the core components of eukaryotic mismatch-repair systems are highly homologous to their bacterial counterparts. In humans, defects in four mismatch-repair genes have been linked both to hereditary non-polyposis colorectal cancer and to spontaneous cancers that exhibit rearrangements in DNA containing simple repeat sequences.
错配修复系统已在从大肠杆菌到人类等多种生物体中被发现。它们几乎可以修复所有DNA碱基对错配以及小的插入/缺失错配。分子和生化分析表明，真核生物错配修复系统的核心成分与其细菌对应物高度同源。在人类中，四个错配修复基因的缺陷已与遗传性非息肉病性结直肠癌以及在含有简单重复序列的DNA中表现出重排的自发性癌症相关联。
