Olsen S F, Hansen H S, Secher N J, Jensen B, Sandström B
Institute of Epidemiology and Social Medicine, University of Arhus, Denmark.
Br J Nutr. 1995 Mar;73(3):397-404. doi: 10.1079/bjn19950042.
It has been hypothesized that marine n-3 fatty acids ingested during pregnancy prolong duration of pregnancy and increase fetal growth rate in humans. By a combined self-administered questionnaire and interview applied in the 30th week of gestation we assessed dietary intake of marine n-3 fatty acids and energy in a population-based sample of 965 pregnant Danish women; in a random 14% subsample we also measured marine n-3 fatty acids relative to arachidonic acid (FA-ratio) in erythrocytes. Mean intake of marine n-3 fatty acids was 0.25 (95% range 0-0.75) g/d. We could detect no association between n-3 fatty acid intake and FA-ratio on the one hand, and gestation length, birth weight and birth length on the other. The analyses were adjusted for maternal height, prepregnant weight, parity and smoking. The conclusion from the study was that within the intake range of this population, marine n-3 fatty acids ingested in the weeks prior to the 30th week of pregnancy seem not to be a predictor of gestation length or fetal growth rate.
据推测，孕期摄入海洋n-3脂肪酸可延长人类孕期并提高胎儿生长速度。在妊娠第30周时，我们采用自填问卷和访谈相结合的方式，对965名丹麦孕妇的人群样本进行了调查，评估了她们对海洋n-3脂肪酸和能量的膳食摄入量；在随机抽取的14%的子样本中，我们还测量了红细胞中海洋n-3脂肪酸与花生四烯酸的比例（脂肪酸比例）。海洋n-3脂肪酸的平均摄入量为0.25（95%范围为0-0.75）克/天。一方面，我们未发现n-3脂肪酸摄入量和脂肪酸比例与另一方面的孕期长度、出生体重和出生身长之间存在关联。分析对孕妇的身高、孕前体重、产次和吸烟情况进行了校正。该研究的结论是，在该人群的摄入量范围内，妊娠第30周前几周摄入的海洋n-3脂肪酸似乎不是孕期长度或胎儿生长速度的预测指标。
