采用毛细管区带电泳法和液相色谱法对福辛普利钠进行定量分析。

Quantitative analysis of fosinopril sodium by capillary zone electrophoresis and liquid chromatography.

作者信息

Lozano R, Warren F V, Perlman S, Joseph J M

机构信息

Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, NJ 08903-0191, USA.

出版信息

J Pharm Biomed Anal. 1995 Feb;13(2):139-48. doi: 10.1016/0731-7085(94)00136-p.

DOI:10.1016/0731-7085(94)00136-p

PMID:7766720

Abstract

A capillary zone electrophoresis (CZE) method was developed for the quantitative analysis of fosinopril sodium. Validation parameters of the CZE method were evaluated and compared to an existing LC method. In terms of precision and sensitivity. LC performance was superior to that of the CZE method for this application. The CZE method achieved better selectivity for several degradants of interest within a much shorter analysis time than did the LC method. Effects of detection wavelength, applied voltage and buffer concentration on optimization of the CZE method are presented. Effects of diluent composition on capillary loading and peak behaviour are also discussed.

摘要

建立了一种用于福辛普利钠定量分析的毛细管区带电泳（CZE）方法。评估了该CZE方法的验证参数，并与现有的液相色谱（LC）方法进行了比较。在精密度和灵敏度方面，对于此应用，LC的性能优于CZE方法。CZE方法在比LC方法短得多的分析时间内，对几种目标降解产物实现了更好的选择性。介绍了检测波长、施加电压和缓冲液浓度对CZE方法优化的影响。还讨论了稀释剂组成对毛细管进样量和峰行为的影响。