Burchfiel C M, Marcus E B, Curb J D, Maclean C J, Vollmer W M, Johnson L R, Fong K O, Rodriguez B L, Masaki K H, Buist A S
Honolulu Epidemiology Research Section, National Heart, Lung, and Blood Institute, Honolulu, Hawaii, USA.
Am J Respir Crit Care Med. 1995 Jun;151(6):1778-85. doi: 10.1164/ajrccm.151.6.7767520.
Effects of cigarette smoking and smoking cessation on rate of FEV1 decline over 6 yr were examined in 4,451 Japanese-American men from the Honolulu Heart Program who were 45 to 68 yr of age at baseline (1965-1968). Within-person regression was used to calculate annual change in FEV1. Rates of FEV1 decline varied strongly with smoking status and increased significantly with age. Overall, men who continued to smoke experienced steeper rates of decline compared with men who never smoked (-33 ml/yr versus -22 ml/yr, respectively; p = 0.0001). Rates of decline for those who quit smoking during the first 2 yr (-32 ml/yr) were nearly the same as those who continued smoking (-34 ml/yr). After quitting, their rates of decline diminished to a level (-19 ml/yr) similar to that of men who had never smoked (-21 ml/yr). FEV1 decline in continuing smokers was significantly associated with duration of smoking, whereas associations with intensity and pack-years were of borderline significance. Among 216 men with impaired pulmonary function, those who quit smoking had significantly slower rates of FEV1 decline than did those who continued smoking. Potential reasons for quitting included respiratory conditions and stroke. These results extend previous reports of accelerated rates of FEV1 decline in the persons who continue to smoke, and they indicate that smoking cessation leads to less steep rates of decline in pulmonary function over a short period of time in middle-aged men, as well as in men with established pulmonary impairment.
在来自檀香山心脏项目的4451名日裔美国男性中，研究了吸烟和戒烟对6年期间第一秒用力呼气容积（FEV1）下降速率的影响，这些男性在基线时（1965 - 1968年）年龄为45至68岁。采用个体内回归来计算FEV1的年度变化。FEV1下降速率因吸烟状况而有很大差异，并随年龄显著增加。总体而言，持续吸烟的男性与从不吸烟的男性相比，FEV1下降速率更快（分别为-33毫升/年和-22毫升/年；p = 0.0001）。在最初2年内戒烟者的下降速率（-32毫升/年）与持续吸烟者的下降速率（-34毫升/年）几乎相同。戒烟后，他们的下降速率降至与从不吸烟男性相似的水平（-19毫升/年）（从不吸烟男性为-21毫升/年）。持续吸烟者的FEV1下降与吸烟持续时间显著相关，而与吸烟强度和吸烟包年数的相关性处于临界显著水平。在216名肺功能受损的男性中，戒烟者的FEV1下降速率明显慢于持续吸烟者。戒烟的潜在原因包括呼吸系统疾病和中风。这些结果扩展了先前关于持续吸烟者FEV1下降速率加快的报道，并且表明戒烟在短期内可使中年男性以及已有肺功能损害的男性的肺功能下降速率减缓。
