Burchfiel C M, Enright P L, Sharp D S, Chyou P H, Rodriguez B L, Curb J D
Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Honolulu, HI 96813, USA.
Chest. 1997 Jul;112(1):87-97. doi: 10.1378/chest.112.1.87.
To identify lifestyle, anthropometric, biochemical, and clinical characteristics associated with pulmonary function in elderly men.
Cross-sectional population-based study.
Japanese-American men (n=3,111) aged 71 to 93 years, who completed spirometry at the fourth examination of the Honolulu Heart Program (1991 to 1993).
Pulmonary function measurements (FEV1 and FVC) were obtained using American Thoracic Society guidelines. Potential factors associated with pulmonary function were examined using Pearson correlation coefficients and general linear models. Age- and height-adjusted mean levels of FEV1 and FVC were compared across quintiles of continuous variables and by status of prevalent disease and medication or vitamin use. Stepwise multiple linear regression was used to identify factors independently associated with pulmonary function overall and among never smokers.
A number of correlates of pulmonary function were initially identified. In multivariate analyses, age, current smoking, pack-years of smoking, emphysema, asthma, wheezing without colds, subscapular skinfold thickness, ECG abnormality, heart rate, WBC count, and eosinophil count were all negatively and independently associated with FEV1, while height, grip strength, physical activity, and mean corpuscular hemoglobin concentration were positively associated. With a few exceptions, similar relations were observed with FVC and among never-smokers.
Cigarette smoking, respiratory symptoms and disease, and several cardiovascular risk factors were independently associated with pulmonary function in elderly Japanese-American men. In most cases, inadequate control for smoking does not appear to account for these associations. Results suggest that a number of factors that are correlates of FEV1 and FVC in younger age groups are also associated with pulmonary function beyond the age of 70 years.
确定与老年男性肺功能相关的生活方式、人体测量学、生化和临床特征。
基于人群的横断面研究。
日裔美国男性（n = 3111），年龄在71至93岁之间，他们在檀香山心脏项目的第四次检查（1991年至1993年）时完成了肺活量测定。
使用美国胸科学会指南进行肺功能测量（第一秒用力呼气容积[FEV1]和用力肺活量[FVC]）。使用Pearson相关系数和一般线性模型检查与肺功能相关的潜在因素。对连续变量的五分位数以及根据常见疾病状态和药物或维生素使用情况比较年龄和身高调整后的FEV1和FVC平均水平。采用逐步多元线性回归来确定与总体肺功能以及从不吸烟者的肺功能独立相关的因素。
最初确定了许多与肺功能相关的因素。在多变量分析中，年龄、当前吸烟状况、吸烟包年数、肺气肿、哮喘、无感冒时的喘息、肩胛下皮褶厚度、心电图异常、心率、白细胞计数和嗜酸性粒细胞计数均与FEV1呈负相关且独立相关，而身高、握力、身体活动和平均红细胞血红蛋白浓度呈正相关。除了少数例外情况，FVC以及从不吸烟者中也观察到了类似的关系。
吸烟、呼吸道症状和疾病以及一些心血管危险因素与老年日裔美国男性的肺功能独立相关。在大多数情况下，对吸烟控制不足似乎并不能解释这些关联。结果表明，在较年轻年龄组中与FEV1和FVC相关的一些因素在70岁以上人群中也与肺功能相关。
