Andersson L, Haley C S, Ellegren H, Knott S A, Johansson M, Andersson K, Andersson-Eklund L, Edfors-Lilja I, Fredholm M, Hansson I
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala.
Science. 1994 Mar 25;263(5154):1771-4. doi: 10.1126/science.8134840.
The European wild boar was crossed with the domesticated Large White pig to genetically dissect phenotypic differences between these populations for growth and fat deposition. The most important effects were clustered on chromosome 4, with a single region accounting for a large part of the breed difference in growth rate, fatness, and length of the small intestine. The study is an advance in genome analyses and documents the usefulness of crosses between divergent outbred populations for the detection and characterization of quantitative trait loci. The genetic mapping of a major locus for fat deposition in the pig could have implications for understanding human obesity.
欧洲野猪与家养大白猪杂交，以便从基因层面剖析这些种群在生长和脂肪沉积方面的表型差异。最重要的效应集中在4号染色体上，其中一个区域在很大程度上解释了品种间在生长速度、肥胖程度和小肠长度方面的差异。这项研究是基因组分析的一项进展，证明了不同远交种群之间的杂交对于检测和鉴定数量性状基因座的有用性。猪中一个主要脂肪沉积基因座的遗传图谱绘制可能对理解人类肥胖症有重要意义。
