Shtarbova M, Klein S
Faculty Hospital of Orthopaedics and Traumatology, Medical University, Sofia, Bulgaria.
Int Orthop. 1995;19(1):51-4. doi: 10.1007/BF00184915.
Operative stress, blood loss and transfusion affect general and local immunity after operation. This study concerns the humoral immunity mediators IgG, IgM and IgA. In 16 patients who had total hip replacements blood loss was made up by transfusion of the patient's own blood and with homologous blood; the immunoglobulins showed a significant reduction compared to the preoperative values. The same was true in a second group of 16 patients who had hip replacement and total homologous transfusion. A third group of 17 patients who had femoral and pelvic osteotomies were given autologous blood, donated before operation, and no changes were found in the immunoglobulins compared with the preoperative values. These results indicate the immunosuppressive effect of homologous transfusion. The balance of immunoglobulins remains relatively stable when blood loss is replaced with the patient's own blood.
手术应激、失血和输血会影响术后的全身及局部免疫。本研究关注体液免疫介质免疫球蛋白G（IgG）、免疫球蛋白M（IgM）和免疫球蛋白A（IgA）。在16例行全髋关节置换术的患者中，分别通过输注患者自身血液和异体血来补充失血；与术前值相比，免疫球蛋白显著降低。在另一组16例行髋关节置换术并接受全异体输血的患者中情况相同。第三组17例行股骨和骨盆截骨术的患者输注术前采集的自体血，与术前值相比，免疫球蛋白未发现变化。这些结果表明异体输血具有免疫抑制作用。当用患者自身血液补充失血时，免疫球蛋白的平衡保持相对稳定。
