LeGrange S N, Breitschwerdt E B, Grindem C B, Beutler E
Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.
J Am Vet Med Assoc. 1995 Apr 1;206(7):1002-6.
A 2-year-old spayed female Shetland Sheepdog had recurrent episodes of discolored urine. Treatments administered for presumed urinary tract infection did not prevent recurrence. Episodes of pigmenturia appeared to correlate with stressful situations or excessive activity. Examination of urine sediment consistently revealed that RBC were not evident, despite a positive result for blood on urinalysis. This was suggestive of hemoglobinuria, and diagnostic testing was instituted to determine the underlying cause. Results of alkaline and osmotic fragility tests were useful in determining that an increase in erythrocyte fragility was the underlying cause of the recurrent pigmenturia. Erythrocyte fragility testing should be considered in animals that do not respond to appropriate treatments for pigmenturia.
一只2岁已绝育的雌性设得兰牧羊犬反复出现尿液变色的情况。针对疑似尿路感染所进行的治疗并未能阻止复发。色素尿发作似乎与应激情况或过度活动有关。尽管尿液分析显示血液呈阳性，但对尿沉渣的检查始终表明红细胞不明显。这提示为血红蛋白尿，并开展了诊断测试以确定潜在病因。碱性和渗透脆性试验的结果有助于确定红细胞脆性增加是复发性色素尿的潜在病因。对于色素尿经适当治疗无反应的动物，应考虑进行红细胞脆性检测。
