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天蓝色链霉菌的葡萄糖激酶基因对于chi63启动子的葡萄糖阻遏作用并非必需。

The glucose kinase gene of Streptomyces coelicolor is not required for glucose repression of the chi63 promoter.

作者信息

Ingram C, Westpheling J

机构信息

Molecular Biology Graduate Program, University of Pennsylvania, Philadelphia, USA.

出版信息

J Bacteriol. 1995 Jun;177(12):3587-8. doi: 10.1128/jb.177.12.3587-3588.1995.

DOI:10.1128/jb.177.12.3587-3588.1995
PMID:7768870
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC177066/
Abstract

Glucose kinase is required for glucose repression of several catabolite-controlled genes in Streptomyces coelicolor and certainly plays an important role in glucose repression in these organisms. We report here that glucose kinase null mutants of S. coelicolor retain transcriptional regulation of the chitinase 63 gene, which encodes an enzyme involved in chitin utilization. Transcription of chi63 is glucose sensitive and chitin dependent. We suggest that glucose repression of chi63 is independent of glucose kinase and that there may be more than one mechanism of glucose repression in Streptomyces spp.

摘要

葡萄糖激酶对于天蓝色链霉菌中几个受分解代谢物控制的基因的葡萄糖阻遏是必需的，并且在这些生物体的葡萄糖阻遏中肯定起着重要作用。我们在此报告，天蓝色链霉菌的葡萄糖激酶缺失突变体保留了几丁质酶63基因的转录调控，该基因编码一种参与几丁质利用的酶。chi63的转录对葡萄糖敏感且依赖于几丁质。我们认为chi63的葡萄糖阻遏不依赖于葡萄糖激酶，并且在链霉菌属中可能存在不止一种葡萄糖阻遏机制。

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1
The glucose kinase gene of Streptomyces coelicolor is not required for glucose repression of the chi63 promoter.天蓝色链霉菌的葡萄糖激酶基因对于chi63启动子的葡萄糖阻遏作用并非必需。
J Bacteriol. 1995 Jun;177(12):3587-8. doi: 10.1128/jb.177.12.3587-3588.1995.
2
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3
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本文引用的文献

1
Glucose kinase has a regulatory role in carbon catabolite repression in Streptomyces coelicolor.葡萄糖激酶在天蓝色链霉菌的碳分解代谢物阻遏中具有调节作用。
J Bacteriol. 1994 May;176(9):2694-8. doi: 10.1128/jb.176.9.2694-2698.1994.
2
Genetic and biochemical evidence for hexokinase PII as a key enzyme involved in carbon catabolite repression in yeast.己糖激酶PII作为参与酵母中碳分解代谢物阻遏的关键酶的遗传和生化证据。
Mol Gen Genet. 1980;178(3):633-7. doi: 10.1007/BF00337871.
3
Glycerol catabolic enzymes and their regulation in wild-type and mutant strains of Streptomyces coelicolor A3(2).天蓝色链霉菌A3(2)野生型和突变株中甘油分解代谢酶及其调控
J Gen Microbiol. 1983 May;129(5):1403-13. doi: 10.1099/00221287-129-5-1403.
4
Genetic mapping, cloning and physiological aspects of the glucose kinase gene of Streptomyces coelicolor.天蓝色链霉菌葡萄糖激酶基因的遗传定位、克隆及生理特性
Mol Gen Genet. 1984;196(3):501-7. doi: 10.1007/BF00436199.
5
Characterization of Streptomyces promoter sequences using the Escherichia coli galactokinase gene.利用大肠杆菌半乳糖激酶基因对链霉菌启动子序列进行表征。
Gene. 1985;40(2-3):191-201. doi: 10.1016/0378-1119(85)90042-3.
6
Effects of null mutations in the hexokinase genes of Saccharomyces cerevisiae on catabolite repression.酿酒酵母己糖激酶基因无效突变对分解代谢物阻遏的影响。
Mol Cell Biol. 1986 Nov;6(11):4046-52. doi: 10.1128/mcb.6.11.4046-4052.1986.
7
Cloning and expression of a Streptomyces plicatus chitinase (chitinase-63) in Escherichia coli.褶皱链霉菌几丁质酶（几丁质酶-63）在大肠杆菌中的克隆与表达。
J Biol Chem. 1988 Jan 5;263(1):443-7.
8
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Mol Microbiol. 1988 Mar;2(2):197-208. doi: 10.1111/j.1365-2958.1988.tb00021.x.
9
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Mol Gen Genet. 1987 Jan;206(1):35-44. doi: 10.1007/BF00326533.
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Two transcribing activities are involved in expression of the Streptomyces galactose operon.链霉菌半乳糖操纵子的表达涉及两种转录活动。
J Bacteriol. 1989 Mar;171(3):1355-61. doi: 10.1128/jb.171.3.1355-1361.1989.