Costello C T, Jeske A H
Department of Physical Therapy, University of Texas Medical Branch, Galveston 77555-1028, USA.
Phys Ther. 1995 Jun;75(6):554-63. doi: 10.1093/ptj/75.6.554.
This article presents a review of the literature relating to iontophoresis. This technique has been used in physical therapy to introduce ionic medications through the skin, primarily for a local effect. Recently, there has been increased interest in using this technique for the transdermal delivery of medications, both ionic and nonionic. This article includes an overview of the history of iontophoresis and a discussion of the physico-chemical and biological factors affecting iontophoretic drug transfer for both local and systemic effects. Factors affecting skin injury and techniques for optimizing iontophoretic drug delivery through the use of current modulation, electrode construction, and skin permeation enhancers are also discussed. Clinical applications of iontophoresis in physical therapy and the pharmacology of selected medications are presented. Thoughts for future potential uses of this technique and needs for further research are also discussed.
本文对与离子导入相关的文献进行了综述。该技术已在物理治疗中用于通过皮肤引入离子药物，主要产生局部作用。最近，人们对使用该技术进行离子和非离子药物的透皮给药越来越感兴趣。本文包括离子导入的历史概述，以及对影响离子导入药物局部和全身作用转移的物理化学和生物学因素的讨论。还讨论了影响皮肤损伤的因素以及通过电流调制、电极构造和皮肤渗透促进剂优化离子导入药物递送的技术。介绍了离子导入在物理治疗中的临床应用以及所选药物的药理学。还讨论了该技术未来潜在用途的想法和进一步研究的需求。
