Mele A, Cabib S, Oliverio A
Dipartimento di Genetica e Biologia Molecolare, Universita di Roma La Sapienza, Italy.
Psychopharmacology (Berl). 1995 Feb;117(3):313-7. doi: 10.1007/BF02246106.
The effects of pretreatment with the non-competitive NMDA antagonist (+)MK-801 on the behavioral alterations induced by repeated restraint stress were investigated. Repeatedly stressed (restraint stress 2 h a day x 10 days) mice showed enhanced sensitivity to the inhibitory effects of a low dose of direct dopamine agonist, apomorphine (0.25 mg/kg), on climbing behavior. On the other hand, no changes were observed for the stimulatory effect of the high dose of apomorphine (3 mg/kg) on this behavioral response. Mice pretreated with MK-801 (0.15 mg/kg) before the stressful experience did not show altered response to the low dose of apomorphine (0.25 mg/kg). Finally, ten daily injections with 0.15 mg/kg MK-801 did not affect the behavioral response to the low dose of apomorphine, but enhanced the stimulatory effect of the high dose of the dopaminergic agonist on climbing behavior. Therefore, it is possible that the protective action of MK-801 against stress-induced behavioral alteration is due to changes in sensitivity of postsynaptic receptors.
研究了用非竞争性N-甲基-D-天冬氨酸（NMDA）拮抗剂（+）MK-801预处理对重复束缚应激诱导的行为改变的影响。反复应激（每天束缚应激2小时，共10天）的小鼠对低剂量直接多巴胺激动剂阿扑吗啡（0.25毫克/千克）对攀爬行为的抑制作用表现出增强的敏感性。另一方面，高剂量阿扑吗啡（3毫克/千克）对这种行为反应的刺激作用未观察到变化。在应激经历前用MK-801（0.15毫克/千克）预处理的小鼠对低剂量阿扑吗啡（0.25毫克/千克）的反应未显示改变。最后，每天注射0.15毫克/千克MK-801十次不影响对低剂量阿扑吗啡的行为反应，但增强了高剂量多巴胺能激动剂对攀爬行为的刺激作用。因此，MK-801对应激诱导的行为改变的保护作用可能是由于突触后受体敏感性的变化。
