Tatarskiĭ A R, Alieva K M, Buriachkovskaia L I, Petrova L E, Bobkov E V, Chuchalin A G
Ter Arkh. 1995;67(3):39-40.
Morphological characteristics of platelets were assessed electron microscopically in 15 patients with atopic and aspirin bronchial asthma (BA) before and after thrombocytapheresis (TA). All the patients had a definite shift of platelet subpopulations to greater percentage of spherical forms as well as defects in cell ultrastructure. This makes evident platelet activation in patients with BA aggravation. TA entails a positive trend to normalization of platelet subpopulations and cytoskeleton. The ability to normalize platelet morphofunctional status determines its clinical effectiveness in bronchial asthma.
在15例特应性和阿司匹林性支气管哮喘（BA）患者进行血小板单采术（TA）前后，通过电子显微镜评估血小板的形态学特征。所有患者的血小板亚群均明显向更高比例的球形转变，同时细胞超微结构存在缺陷。这表明BA加重患者存在血小板活化。TA使血小板亚群和细胞骨架有正常化的积极趋势。使血小板形态功能状态正常化的能力决定了其在支气管哮喘中的临床疗效。
