秋水仙碱对日本血吸虫感染小鼠肝脏糖胺聚糖代谢的影响。

Effect of colchicine on hepatic glycosaminoglycan metabolism in mice infected with Schistosoma japonicum.

作者信息

Si Q, Zhang Y, Wang Q H, Zhuang Q Q, Mei M Z

机构信息

Department of Biochemistry, School of Pharmacy, Shanghai Medical University, China.

出版信息

Zhongguo Yao Li Xue Bao. 1995 Jan;16(1):39-42.

PMID:7771194

Abstract

AIM

To study the effect of colchicine on hepatic glycosaminoglycan (GAG) metabolism in mice infected with Schistosoma japonicum.

METHODS

The amount of GAG was measured in the liver of mice infected with Schistosoma japonicum for 6-16 wk and treated with colchicine.

RESULTS

Six weeks after infection, the GAG content of infected mice's livers and uninfected control was 14 +/- 2 micrograms/g liver and 4 +/- 1 microgram/g liver, respectively. The GAG content reached a peak about 6 times of the normal level in the 10th wk after infection, being 56 +/- 9 micrograms/g and 10 +/- 1 microgram/g for infected and uninfected mice respectively, and then declined. Treatment of infected mice with colchicine reduced the total GAG content to 22 +/- 3 micrograms/g liver, but not suppress the GAG content below the normal level in the 10th wk. Microscopic hepatic egg granuloma.

CONCLUSION

Colchicine may exerts its GAG reduction effect through the suppression of granuloma formation.

摘要

目的

研究秋水仙碱对日本血吸虫感染小鼠肝脏糖胺聚糖（GAG）代谢的影响。

方法

测量感染日本血吸虫6至16周并用秋水仙碱治疗的小鼠肝脏中GAG的含量。

结果

感染后6周，感染小鼠肝脏和未感染对照的GAG含量分别为14±2微克/克肝脏和4±1微克/克肝脏。感染后第10周，GAG含量达到约正常水平6倍的峰值，感染小鼠和未感染小鼠分别为56±9微克/克和10±1微克/克，然后下降。用秋水仙碱治疗感染小鼠可使总GAG含量降至22±3微克/克肝脏，但在第10周时不会将GAG含量抑制至正常水平以下。肝虫卵肉芽肿镜检。