Ichiba T, Matsufuji S, Miyazaki Y, Hayashi S
Department of Nutrition, Jikei University School of Medicine, Tokyo, Japan.
Biochim Biophys Acta. 1995 May 17;1262(1):83-6. doi: 10.1016/0167-4781(95)00062-l.
An ornithine decarboxylase antizyme cDNA was obtained from Xenopus laevis liver and its sequence was determined. The cDNA consists of two major open reading frames as found in mammalian antizymes, which require +1 ribosomal frameshifting for its translation. Sequences important for frameshifting, namely the frameshift site and downstream stimulatory pseudoknot determined in the rat mRNA, are conserved.
从非洲爪蟾肝脏中获得了鸟氨酸脱羧酶抗酶cDNA,并测定了其序列。该cDNA包含两个主要的开放阅读框,如同在哺乳动物抗酶中发现的那样,其翻译需要+1核糖体移码。对于移码重要的序列,即在大鼠mRNA中确定的移码位点和下游刺激假结,是保守的。