Tomoda H, Inoue T
Department of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka, Japan.
J Surg Oncol. 1995 Jun;59(2):101-4. doi: 10.1002/jso.2930590206.
We investigated and compared the DNA content between primary and metastatic lesions from 30 colorectal cancer cases. The findings were only diploid in 2 cases (6.7%) and only aneuploid in 18 cases (60.0%). On the whole, the DNA ploidy agreed in 20 cases (66.7%) between both lesions. In the 18 cases with only aneuploid tumors in both lesions, the DNA index tended to be larger in the metastatic lesions than in the primary lesions. In contrast, a variation in the DNA ploidy was observed in 10 cases (33.3%). These findings show that DNA ploidy tends to remain stable during metastasis in many cases of colorectal cancer, although the DNA index did tend to be larger in metastatic lesions than in primary lesions. The existence of intertumoral heterogeneity in the DNA ploidy also shows that specimens should be investigated from both lesions in order to obtain more accurate information on the tumor and its biological behavior.
我们研究并比较了30例结直肠癌患者原发灶和转移灶之间的DNA含量。结果显示，仅2例（6.7%）为二倍体，18例（60.0%）仅为非整倍体。总体而言，20例（66.7%）患者的两个病灶DNA倍性一致。在两个病灶均仅为非整倍体肿瘤的18例患者中，转移灶的DNA指数往往高于原发灶。相反，10例（33.3%）患者观察到DNA倍性存在差异。这些结果表明，在许多结直肠癌病例中，DNA倍性在转移过程中往往保持稳定，尽管转移灶的DNA指数确实往往高于原发灶。DNA倍性存在肿瘤间异质性这一情况也表明，应同时对两个病灶的标本进行研究，以便获得关于肿瘤及其生物学行为更准确的信息。
