King A A
Central Veterinary Laboratory, New Haw, Weybridge, Surrey, United Kingdom.
Onderstepoort J Vet Res. 1993 Dec;60(4):283-7.
Rabies and rabies-related viruses are divided into four serotypes, although it has been suggested that the inclusion of European bat lyssaviruses results in six genotypes. Sixty-four rabies-related viruses were tested against a panel of 36 anti-nucleocapsid monoclonal antibodies prepared from the immunization of Balb/c mice with five prototypic rabies-related viruses. Reaction patterns obtained confirmed the original distinction between serotype 1-4 viruses and revealed multiple variants of Lagos bat and Mokola viruses. In addition, two biotypes of European bat lyssavirus were identified and a clear distinction was shown between these biotypes and Duvenhage virus of Africa. The origins and importance of the rabies-related viruses are discussed.
狂犬病及狂犬病相关病毒分为四种血清型，不过有人认为纳入欧洲蝙蝠狂犬病病毒后会产生六种基因型。用五种典型的狂犬病相关病毒免疫Balb/c小鼠制备了一组36种抗核衣壳单克隆抗体，并用这组抗体检测了64种狂犬病相关病毒。所得反应模式证实了1-4型病毒之间原有的区别，并揭示了拉各斯蝙蝠病毒和莫科拉病毒的多个变种。此外，鉴定出了欧洲蝙蝠狂犬病病毒的两种生物型，并表明这些生物型与非洲的杜文海格病毒之间存在明显区别。文中还讨论了狂犬病相关病毒的起源及重要性。
