Nikolaeva T N, Bondarenko V M, Nastichkin I A, Belaia Iu A
Zh Mikrobiol Epidemiol Immunobiol. 1995 Jan-Feb(1):33-6.
Fractions of S.flexneri 2a 516 outer membrane proteins determined by plasmid pSF140 have been shown to possess immunomodulating activity and to be capable of influencing the intensity of hematopoiesis, manifested by the stimulation of endocolony formation, the increase of the amount of splenic colony-forming units in the marrow, the increase of the pool of proliferating splenic colony-forming units of the marrow and their intensive migration into the blood. Outer membrane proteins have been shown to produce an immunostimulating effect on the functional activity of effector B-lymphocytes shortly after their injection. On the contrary, S.flexneri 2a 516/4 pSF140- outer membrane proteins produce a less pronounced effect on hematopoietic stem cells and reproduce unspecific immunostimulating effect on the formation of B-cells, synthesizing antibodies to heterologous antigen.
由质粒pSF140决定的福氏志贺菌2a 516外膜蛋白组分已被证明具有免疫调节活性，并且能够影响造血强度，表现为刺激内集落形成、增加骨髓中脾集落形成单位的数量、增加骨髓中增殖性脾集落形成单位的池以及它们向血液中的大量迁移。外膜蛋白在注射后不久已被证明对效应B淋巴细胞的功能活性产生免疫刺激作用。相反，福氏志贺菌2a 516/4 pSF140 -外膜蛋白对造血干细胞产生的作用不太明显，并且对合成针对异源抗原的抗体的B细胞形成产生非特异性免疫刺激作用。
