Ravaoalimalala V A, Rein J, Boisier P, Roux J, Esterre P
Laboratoire Central Bilharzioses-Cysticercose, DLMT, Ministère de la Santé, Antananarivo.
Arch Inst Pasteur Madagascar. 1994;61(1):49-52.
In 1976, 1983, 1986 to 1989 and 1993, the population of Ampefy, on the shores of lake Itasy, was invited to participate in an active detection programme of Schistosoma mansoni infection. An increase in the global prevalence was observed from 1976 (17.0%) to 1983 (40.0%). This prevalence level was then stabilized during the four years annual selective treatment (1986 to 1989) and the mean intensity of infection for positive patients fell from 393 eggs/g to 271 eggs/g and the proportion of severe infections, with a high risk of developing "hepatosplenic disease", fell from 8% to 4.2%. Selective treatment was interrupted from 1989 to 1993, during which time the global prevalence rose to 70.6% and mean intensity of infection to 594 eggs/g, with 22% of those examined classified as severely infested. This local control programme, associating active detection with annual treatment, seems effective in stabilizing prevalence and intensity of infection in spite of a regular arrival of infested, and never treated, immigrants. However, its impact throughout time is limited.
1976年、1983年、1986年至1989年以及1993年，伊塔西湖畔的安佩菲居民受邀参与一项曼氏血吸虫感染主动检测计划。全球患病率从1976年的17.0%上升至1983年的40.0%。随后，在四年的年度选择性治疗期间（1986年至1989年），患病率稳定下来，阳性患者的平均感染强度从393个虫卵/克降至271个虫卵/克，有发展为“肝脾疾病”高风险的重度感染比例从8%降至4.2%。1989年至1993年期间中断了选择性治疗，在此期间，全球患病率升至70.6%，平均感染强度升至594个虫卵/克，接受检查的人群中有22%被归类为重度感染。这项将主动检测与年度治疗相结合的地方控制计划，尽管有受感染且从未接受治疗的移民不断涌入，但在稳定患病率和感染强度方面似乎是有效的。然而，其长期影响是有限的。
