类风湿关节炎来源的免疫复合物中独特的寡糖含量。
Distinct oligosaccharide content of rheumatoid arthritis-derived immune complexes.
作者信息
Bond A, Kerr M A, Hay F C
机构信息
Department of Cellular and Molecular Sciences, St. George's Hospital Medical School, London, UK.
出版信息
Arthritis Rheum. 1995 Jun;38(6):744-9. doi: 10.1002/art.1780380605.
OBJECTIVE
To investigate the association between glycosylation and immune complex formation in various disease groups.
METHODS
Immune complexes and IgG were isolated from serum and their carbohydrate content evaluated in a dot-blot assay using specifically binding lectins.
RESULTS
Significantly more N-acetylglucosamine was detected in complexes from patients with rheumatoid arthritis (RA) than in those from patients with systemic lupus erythematosus, Crohn's disease, or infectious endocarditis, or from normal controls (P < 0.001). The immune complex concentration in the circulation was strongly associated with N-acetylglucosamine levels (P < 0.001 by chi-square analysis).
CONCLUSION
The composition of immune complexes from RA patients is distinct in carbohydrate content from those found in other disease groups.
目的
研究不同疾病组中糖基化与免疫复合物形成之间的关联。
方法
从血清中分离免疫复合物和IgG，并使用特异性结合凝集素通过斑点印迹法评估其碳水化合物含量。
结果
类风湿关节炎（RA）患者的复合物中检测到的N-乙酰葡糖胺明显多于系统性红斑狼疮、克罗恩病、感染性心内膜炎患者或正常对照者（P < 0.001）。循环中的免疫复合物浓度与N-乙酰葡糖胺水平密切相关（卡方分析，P < 0.001）。
结论
RA患者免疫复合物的组成在碳水化合物含量方面与其他疾病组不同。
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