Bond A, Alavi A, Axford J S, Bourke B E, Bruckner F E, Kerr M A, Maxwell J D, Tweed K J, Weldon M J, Youinou P, Hay F C
Division of Immunology, St George's Hospital Medical School, London.
J Autoimmun. 1997 Feb;10(1):77-85. doi: 10.1006/jaut.1996.0104.
Serum IgG from rheumatoid arthritis patients contains a decreased number of oligosaccharide structures ending in galactose and thus there is an increase in N-acetylglucosamine as the terminal sugar, compared with healthy individuals. The relationship between these two sugars varies depending on the disease examined: IgG from patients with rheumatoid arthritis, juvenile onset chronic arthritis and Crohn's disease are at one extreme, and exhibit a reciprocal galactose:N-acetylglucosamine relationship, while Sjögren's syndrome and osteoarthritis IgG are at the other extreme, exhibiting a parallel increase in the expression of both galactose and N-acetylglucosamine. These results may occur as a consequence of more than one glycosylation site which is differentially glycosylated, but more likely by changes in the level of bisecting N-acetylglucosamine.
类风湿关节炎患者的血清IgG中，以半乳糖结尾的寡糖结构数量减少，因此与健康个体相比，作为末端糖的N-乙酰葡糖胺有所增加。这两种糖之间的关系因所研究的疾病而异：类风湿关节炎、幼年型慢性关节炎和克罗恩病患者的IgG处于一个极端，呈现半乳糖与N-乙酰葡糖胺的反向关系，而干燥综合征和骨关节炎患者的IgG则处于另一个极端，半乳糖和N-乙酰葡糖胺的表达呈平行增加。这些结果可能是由于多个糖基化位点发生差异糖基化所致，但更可能是由于平分型N-乙酰葡糖胺水平的变化。
