Carthew P, Edwards R E, Dorman B M, Verschoyle R D
Medical Research Council Toxicology Unit, University of Leicester, UK.
Hum Exp Toxicol. 1995 Feb;14(2):217-20. doi: 10.1177/096032719501400211.
Phenylamino-1,2 propanediol (PAP) and its mono-oleoyl ester have been identified in samples of the cooking oil thought to be responsible for the Toxic Oil Syndrome (TOS) which occurred in Spain in 1981. The acute toxicity of PAP and its mono-oleoyl ester have been examined in rats and mice, after daily administration for periods of up to 14 days to determine whether these compounds could produce any of the pathologies of TOS. Even at the highest dose, the 1-mono-oleoyl ester of 3-phenylamino-1,2 propanediol did not cause any toxicity in rats or mice when given intraperitoneally. 3-Phenylamino-1,2 propanediol, however, was toxic when administered to rats by this route. After 6-10 consecutive daily doses of PAP, at the highest dose administered (350 mg kg-1), all of the rats became unwell. Postmortem examination showed that the major pathology present was massive pulmonary thromboembolism. Further investigations of the toxicity of PAP after intravenous administration showed that it was not directly vasotoxic. The pulmonary thromboembolism seen with intraperitoneally administered PAP was due to the toxic effect of PAP on the mesenteric tissue and blood vessels, causing thrombosis which subsequently embolised the blood vessels in the lung. Intra-gastric administration of PAP caused no toxicity in rats. Comparatively, the pathology seen after intraperitoneal administration of PAP was not thought to be representative of the pathology of the toxic oil syndrome in man.
苯氨基 -1,2 -丙二醇（PAP）及其单油酰酯已在被认为是1981年西班牙发生的有毒油综合征（TOS）致病源的食用油样本中被鉴定出来。在大鼠和小鼠中对PAP及其单油酰酯进行了急性毒性检测，每日给药长达14天，以确定这些化合物是否会引发TOS的任何病理症状。即使在最高剂量下，3 -苯氨基 -1,2 -丙二醇的1 -单油酰酯经腹腔注射给予大鼠或小鼠时也未引起任何毒性。然而，3 -苯氨基 -1,2 -丙二醇经此途径给药时对大鼠有毒性。连续6 - 10天每日给予PAP最高剂量（350 mg kg⁻¹）后，所有大鼠均出现不适。尸检显示主要病理症状为大面积肺血栓栓塞。对静脉注射PAP后的毒性进行的进一步研究表明，它并非直接具有血管毒性。腹腔注射PAP后出现的肺血栓栓塞是由于PAP对肠系膜组织和血管的毒性作用，导致血栓形成，随后栓塞肺部血管。经胃内给予PAP对大鼠无毒性。相比之下，腹腔注射PAP后出现的病理症状不被认为代表人类有毒油综合征的病理情况。
