香豆素诱导的异常凝血因子IX：一项人体免疫学研究
Coumarin-induced abnormal factor IX: an immunological study in humans.
作者信息
Girolami A, Sticchi A, Burul A
出版信息
Folia Haematol Int Mag Klin Morphol Blutforsch. 1978;105(1):117-24.
An excess of factor IX antigen or protein with respect to factor IX activity is present in coumarin treated patients. The average factor IX antigen value found in a group of 16 patients was 96.2 (S.D. = 24.46) whereas the average clotting activity was 19 (S.D. = 4.54) (p less than 0.001). In the electroimmunoassay system a normal peak or precipitate were seen in every instance. In haemophilia B--no peak or precipitate were seen. The coumarin induced abnormal factor IX shows a more anodic migration in the bidimensional immunoelectrophoresis system as compared with the normal counterpart. On the contrary, the factor IX protein present in haemophilia BM or in haemophilie B+ migrates as normal factor IX.
接受香豆素治疗的患者体内存在相对于因子IX活性而言过量的因子IX抗原或蛋白质。在一组16名患者中发现的因子IX抗原平均值为96.2（标准差=24.46），而平均凝血活性为19（标准差=4.54）（p<0.001）。在免疫电泳系统中，每次都能看到正常的峰或沉淀。在乙型血友病患者中则看不到峰或沉淀。与正常的对应物相比，香豆素诱导产生的异常因子IX在双向免疫电泳系统中显示出更多的阳极迁移。相反，存在于B型血友病携带者或乙型血友病患者体内的因子IX蛋白质迁移情况与正常因子IX相同。
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