Lubrithal（利奥粘性眼凝胶）在正常眼和干眼的角膜前停留时间。

Lubrithal (Leo viscous eye gel), precorneal residence time in normal and dry eyes.

作者信息

al-Mansouri S, Tabbara K F, Rask-Pedersen E

机构信息

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

出版信息

Doc Ophthalmol. 1994;88(2):187-94. doi: 10.1007/BF01204617.

DOI:10.1007/BF01204617

PMID:7781487

Abstract

In an open, right/left controlled study we compared the effects of topical carbomer gel Lubrithal (Leo viscous eye gel) and polyvinyl alcohol (Liquifilm, Allergan) in 20 patients with dry eyes and in 20 healthy subjects. The average precorneal residence time of carbomer gel in patients and healthy subjects was 92.8 min (+/- 35.7) and 36.5 min (+/- 14.2), respectively, while it was 40.8 min (+/- 19.4) and 19.5 min (+/- 8.3) in the polyvinyl alcohol group. The tear break up time was 10 min after instillation significantly longer with the carbomer gel: 23.0 seconds (+/- 5.5) in dry eye patients and 26.2 seconds (+/- 4.4) in healthy subjects compared to polyvinyl alcohol: 10.4 seconds (+/- 3.4) in dry eye patients and 16.5 seconds (+/- 7.1) in healthy subjects (p < 0.001). Seventy-five per cent of the dry eye patients preferred Lubrithal.

摘要

在一项开放性、左右对照研究中，我们比较了局部用卡波姆凝胶Lubrithal（利奥粘性眼凝胶）和聚乙烯醇（泪然，爱尔康）对20例干眼症患者及20名健康受试者的效果。卡波姆凝胶在患者和健康受试者中的平均角膜前滞留时间分别为92.8分钟（±35.7）和36.5分钟（±14.2），而聚乙烯醇组分别为40.8分钟（±19.4）和19.5分钟（±8.3）。滴入后泪膜破裂时间在卡波姆凝胶组显著更长：干眼症患者为23.0秒（±5.5），健康受试者为26.2秒（±4.4），相比之下聚乙烯醇组干眼症患者为10.4秒（±3.4），健康受试者为16.5秒（±7.1）（p<0.001）。75%的干眼症患者更喜欢Lubrithal。