Maroon J C, Holst R A, Osgood C P
J Neurol Neurosurg Psychiatry. 1976 May;39(5):508-13. doi: 10.1136/jnnp.39.5.508.
The results of chemonucleolysis in 48 patients with lumbar disc disease revealed marked improvement in 58%, slight improvement in 23%, and no improvement in 19%. Serious anaphylactic reactions occurred in two patients. These results and those of other neurosurgical and orthopaedic studies are summarized and compared with the 70% improvement rate obtained with a placebo in a recent double blind controlled cooperative study. Only those few investigators participating in the double blind study are now permitted to use intradiscal chymopapain. It is concluded that the ultimate place of chemonucleolysis, if any, in the treatment of ruptured lumbar discs remains to be determined.
48例腰椎间盘疾病患者的化学髓核溶解术结果显示，58%的患者有显著改善，23%的患者有轻微改善，19%的患者无改善。两名患者发生了严重的过敏反应。总结了这些结果以及其他神经外科和骨科研究的结果，并与最近一项双盲对照合作研究中安慰剂获得的70%改善率进行了比较。现在仅允许参与双盲研究的少数研究者使用椎间盘内木瓜凝乳蛋白酶。得出的结论是，化学髓核溶解术在治疗破裂腰椎间盘方面（如果有）的最终地位仍有待确定。
